Fluorometric screening method for detecting benzodiazepines in blood and urine.
نویسندگان
چکیده
We report a fluorometric method for detecting diazepam, chlordiazepoxide, oxazepam, chlorazepate, and (or) their major metabolites in blood, urine, or gastric contents at low therapeutic concentrations. The drugs are first hydrolyzed to their respective benzophenones and converted to highly fluorescent 9-acridanones. Total benzodiazepines (parent plus metabolites) in blood and gastric contents are semiquantitatively evaluated and compared to results of gas-chromatographic determinations.
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ورودعنوان ژورنال:
- Clinical chemistry
دوره 21 13 شماره
صفحات -
تاریخ انتشار 1975